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Purpose To evaluate the therapeutic effect of laser-induced chorioretinal venous anastomosis for retinal vein occlusion (RVO)． Methods The investigation included 28 consecutive patients (28 eyes) with RVO．The non-ischemic group 18 cases (18 eyes) were treated with the krypton red laser to induce chorioretinal venous anastomosis， the ischemic group underwent the same therapy and the grid or scatter-type photocoagulation at the same time． All of the eyes were followed up for more than 5 months， and with an average period of 6．6 months． Results Seven cases (7 eyes， 38．9%) of the non-ischemic group created successful chorioretinal venous anastomosis， with mean improvement of 4．43±0．78 standard deviation （±s） lines of best-corrected visual acuity compared to 0．19±0．67 （±s） lines for 11 eyes with unsuccessful anastomosis (P<0．001)． None of the seven eyes developed to ischemic state． Four of the 11 eyes with unsuccessful anastomosis converted to ischemic type (36．4%)． Two cases of the ischemic group created successful anastomosis with improvement in visual acuity． The other cases had no change in visual acuity． Conclusion Laser-induced chorioretinal venous anastomosis is a new therapeutic method for RVO， especially for nonischemic type and successful anastomosis can decrease the conversion rate of the vein occlusion to an ischemic state．
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Objectives To evaluate the effect of peeling of internal limiting membrane (ILM) on the post-operative visual acuity in patients with diabetic macular edema, and to detect the role indocyanine green (ICG) plays in the surgery of peeling of ILM. Methods Thirty patients (31 eyes) with diabetic retinopathy at proliferative stage with macular edema underwent vitrectomy. The patients were randomly divided into two groups: 16 eyes in group A underwent single vitrectomy with panretinal photocoagulation and ocular filling with 20% SF6; 15 eyes in group B underwent vitrectomy and peeling of ILM after the posterior pole was stained with ICG. All of the patients were asked to keep the posture of facing down for 10-14 days. The follow-up lasted 3-12 months. Results In 16 eyes in group A, the visual acuity increase of 2 or more lines in 10 (62.5%) and alleviation of macular edema in 9 (56.2%) were found; the postoperative average macular retinal thickness examined by optic coherence tomography (OCT) was 393 ?m. In 15 eyes in group B, the visual acuity increase of 2 or more lines in 14 (93.3%) and alleviation of macular edema in 14 (93.3%) were found; the postoperative average macular retinal thickness was 319 ?m. The postoperative improvement of visual acuity in group B was much better than that in group A ( ? 2=4.210, P =0.05), while the postoperative macular retinal thickness in group B was obviously lower than that in group A ( P
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Objective To investigate the effect of bromocriptine on rats with experimental autoimmune uveoretinitis. Methods Tweenty four Wistar rats were immunized by bovine soluble antigen and randomly divided into treatment and control group. The rats in treatment group took bromocriptine orally with the dosage of 5 mg/(kg?d), which could inhibit prolactin (PRL) deliverance, while the rats in control group took glucose solution orally with the dosage of 50 g/(L?d). The clinical changes of all the rats and the delayed type hypersensitivity (DTH) response were detected. The rats were anesthetized and killed after immunized for 21 days, and the eyes were removed and examined histologically. Results The occurrence of EAU and histology scores of rats in treatment group were lower than the controls ( P 0.05). Conclusions Bromocriptine can generally inhibit PRL deliverance, and may also inhibit the occurrence of EAU in rats through neuroendocrine immune regulating network.
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Objective To evaluate the therapeutic effect of laser induced chorioretinal venous anastomosis on macular edema of non ischemic retinal vein occlusion. Methods Thirty seven eyes of 37 cases of non ischemic retinal vein occlusion received the treatment of laser induced chorioretinal venous anastomosis and were followed up for 6～12 months. All affected eyes underwent the clinical examinations of visual acuity, ocular fundus photography, fundus fluoreceine angoigraphy (FFA) and light sensitivity of central 5 degree of the retina, and the pre and post operative clinical materials were analyzed. Results Successful chorioretinal venous anastomosis was formed in 18 eyes (48.6%) within 2 months after laser photocoaglation, with the mean best improved corrected visual acuity of (4 25?0 46) lines, while the mean best corrected visual acuity of the other 19 eyes with unsuccessful anastomosis decreased (0 20?0 54) lines ( P
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Objective To inspect the rate of success of anastomosis and tissue damage with different power levels of photocoagulation in the treatment of experimental branch retinal vein occlusion (BRVO) by laser induced chorioretinal venous anastomosis. Methods Forty pigmented rabbits (80 eyes) were divided into four groups in random, and 10 (20 eyes) in each. Chroioretinal venous anastomosis was attempted to create using the krypton red laser with 4 different power levels (group A: 400 mW,group B: 600 mW,group C: 800 mW,group D: 1000 mW) in these animals in which BRVO had previously been created photodynamically. Fundus photography and fundus fluorescein angiography were performed at various times after the treatment and histological examination was taken at the end of the study. Results The model of BRVO was successfully set up. At the lowest power of 400 mW there was an absence of anastomosis formation and the damage to the retina and choroid was mild, Bruch′s membrane showed no evidence of rupture. At the power levels of 600 mW and 800 mW an anastomosis formed in 15% and 55% respectively and the damage was medium in degree. At the highest power level of 1 000 mW a 80% rate of success was obtained, however, the damage to the retina and choroid tended to be severe. The difference of the rate of success of anastomosis between different groups was highly significant ( P =0 001), the difference between group B and group C was also highly significant ( P BC =0.008), and the difference between group A and group B, group C and group D was not significant ( P AB =0 072、 P CD =0 091). Conclusion The optimal power level of krypton red laser induced chorioretinal venous anastomosis is 800 mW, 0.1 s, 50 ?m in our study.
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Objective To evaluate the efficacy of stellate ganglion block ( SGB) in the treatment of ischemic optic neuropathy ( ION ) as compared with that of steroids. Methods Eighty-two eyes were involved in seventy patients with ION. The patients were randomly assigned to receive either steroids (dexamethason 15 mg iv q.d. for 5-10 days followed by peroral prednisone 20 mg q.d.) ( n = 34, 38 eyes) or ipsilateral SGB (2% lidocaine 2-3 ml q.d. 10-15 days) ( n = 36, 44 eyes). The criteria for judging the efficacy of the treatment were changes in visual acuity, ocular fundus, visual field and visual evoked potential (VEP) . The effectiveness of the treatment was divided into four grades : excellent, good, improved and no effect. Results In steroid group the results of treatment were rated as excellent for 10, good for 12, improved for 3 and no effect for 13 eyes (the overall success rate was 65.8%), while in SGB group the results were rated as excellent for 15, good for 14, improved for 5 and no effect for 10 eyes ( the overall success rate was 77.3 % ). In patients who were successfully treated, the visual acuity improved, the pale edema of optic papilla was disappearing and the color and blood vessels of retina were returning to normal. The latent time of VEP P100 was significantly shortened and the amplitude increased in both groups. Conclusion SGB is a safe, reliable and effective method of treatment for ION.